Breakthrough in Understanding Aging Skin Will Lead to New Anti-Aging Products

The Newcastle Team’s research not only helps us to understand aging in skin cells, but also may provide researchers with the ability to study the aging process elsewhere in the body and see if this same biomarker can be used to test new anti-aging therapies and treatments targeted to them.

The informative Science Daily press release continues:

“There is now a possibility of finding anti-ageing treatments which can be tailored to differently aged and differently pigmented skin, and with the additional possibility to address the ageing process elsewhere in our bodies.”

Complex II activity was measured in 27 donors, from aged six to 72 years. Samples were taken from a sun-protected area of skin to determine if there was a difference in activity with increasing age.

Techniques were used to measure the activities of the key enzymes within mitochondria that are involved in producing the skin cell’s energy, a type of mitochondrial gym or skin physical. This was applied to cells derived from the upper (epidermis) and lower (dermis) levels of skin.

It was found that complex II activity significantly declined with age, per unit of mitochondria, in the cells derived from the lower rather than the upper levels, an observation not previously reported for human skin.

The scientists found that the reason for this is the amount of enzyme protein was decreased and furthermore this decrease was only observed in those cells that had stopped proliferating.

Further studies will now be required to fully understand the functional consequences in skin and other tissues, and to establish methods to assess anti-ageing strategies in human skin.


This breakthrough research is only the beginning, stay tuned for more as this line of investigation continues. For additional details on this study, please see the excellent news release on the Science Daily website.

Source: – “Scientists make significant anti-aging breakthrough

Featured Image Credit: Newcastle University, photo of Prof. Mark Birch-Machin, lead researcher.

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